17-Hydroxyprogesterone, LC/MS/MS Blood Test

The 17-hydroxyprogesterone blood test measures the level of 17-hydroxyprogesterone (17-OHP) in the blood. 17-OHP is a steroid hormone produced in the adrenal glands and gonads.

What Does the 17-Hydroxyprogesterone Test Measure?

This test measures the amount of 17-OHP present in the bloodstream. 17-OHP is one of the main precursors for the production of cortisol, aldosterone and sex hormones like testosterone and estrogen. An abnormally high level of 17-OHP indicates a condition called congenital adrenal hyperplasia (CAH), which is caused by a genetic defect that affects an enzyme needed to produce cortisol.

The most common form of CAH is due to 21-hydroxylase deficiency. Without enough 21-hydroxylase, the adrenal glands and gonads overproduce 17-OHP. Increased 17-OHP is then shunted into the production of androgens like testosterone. This can lead to masculinization and early puberty in children.

Who Should Get a 17-Hydroxyprogesterone Test?

A 17-OHP test may be recommended for:

• Infants with ambiguous genitalia or virilization
• Women with irregular periods, infertility or symptoms of high androgens like excess hair growth
• Monitoring CAH treatment
• Workup for adrenal and gonadal tumors

The test is often performed in newborns as part of congenital adrenal hyperplasia screening programs. It can help identify CAH early and prevent complications through prompt treatment.

Preparing for the 17-Hydroxyprogesterone Test

No special preparation is needed for this test. However, the following tips can help ensure accurate results:

• The blood draw should be done in the morning. 17-OHP levels vary throughout the day.
• Women who are not on birth control pills may be instructed to have the test done in the follicular phase of their menstrual cycle.
• A repeat test may be needed for confirmation if the initial result is abnormal.

Understanding the Results of 17-OHP Testing

Normal values differ based on age, sex and testing methods. In general, normal 17-OHP levels are:

• Newborns: Less than 150 ng/dL
• Children: Less than 200 ng/dL
• Adults: Less than 270 ng/dL in women and 400 ng/dL in men

An elevated level indicates excess production of 17-OHP. Your doctor will interpret your actual lab result based on your symptoms and health history. A high 17-OHP level may prompt genetic testing for CAH or imaging tests to look for tumors. Your doctor may also order other hormone tests or suggest treatment to normalize your 17-OHP level.

Where Can I Get 17-Hydroxyprogesterone Testing Near Me?

This test requires a blood sample, which can be collected at one of our 4,000+ affiliated labs across the country. Order your test online and get same-day lab testing at a location near your home or office. We work with national lab providers like Quest Diagnostics to make 17-hydroxyprogesterone testing accessible. With Personalabs you can view test prices upfront and get your results within just 1-3 days on our secure patient portal.

Tests Included:

Estimated Turn Around For Results:

2-10 Business Days

For an exact turnaround time for results, please contact us at Personalabs and we will contact the lab on your behalf as turnaround times vary depending on testing location or lab testing provider.